Abstract. Background. One of the treatment modalities for ectopic pregnancy is methotrexate. The purpose of this study is to identify the failure rate of methotrexate in treating patients with ectopic pregnancy as well as the risk factors leading to treatment failure. This feature is not available right now. Please try again later. A Cochrane analysis and three underpowered prospective randomized trials did not provide an adequate data base for a reliable comparison of fertility rates after tube-preserving surgery and drug treatment with methotrexate (29, 39). If you have low levels of hCG -- a hormone your body makes when you’re pregnant and there’s no damage to the fallopian tube, your doctor can give you an injection of a drug called methotrexate. Ectopic pregnancy can lead to fallopian tube rupture. If that happens, you could have major pain with or without severe bleeding. Or the bleeding could be internal. Call your doctor immediately if. Methods. This was a retrospective review of 60 cases of ectopic pregnancy treated with single dose methotrexate in Nizwa hospital, Oman. Demographic data, clinical presentation, treatment progress, outcome, side effects and future fertility follow up were analysed using a computer database. There's also a chance of your fallopian tube rupturing after treatment. You'll be told what to look out for and what to do if you think this has happened. You'll be told what to look out for and what to do if you think this has happened. If an ectopic pregnancy is left to develop, there is a risk that the fertilised egg could continue to grow and cause the fallopian tube to split open (rupture), which can cause life-threatening internal bleeding. Methotrexate recovery experience and doctor frustration after ectopic pregnancy.